Tag: cognitive decline

tricyclic antidepressants anticholinergic burden cognitive decline cardiac risks amitriptyline

Anticholinergic Burden with Tricyclic Antidepressants: Cognitive and Cardiac Risks

Tricyclic antidepressants like amitriptyline carry high anticholinergic burden, increasing risks of cognitive decline and dangerous heart rhythm changes. Safer alternatives exist, and many side effects can be reversed by switching medications.

December 15 2025