Avanafil Dosage: What You Need to Know About Strengths, Timing, and Safety

When you're looking for a fast-acting solution for erectile dysfunction, Avanafil, a prescription medication used to treat ED by increasing blood flow to the penis. Also known as Stendra, it works in as little as 15 minutes and lasts up to six hours—making it one of the quickest options on the market. Unlike older ED drugs that require planning hours ahead, Avanafil fits into spontaneous moments. But getting the Avanafil dosage right matters just as much as timing. Too little and it won’t work. Too much and you risk side effects like headaches, flushing, or dizziness.

Most people start with a 100 mg dose taken about 30 minutes before sex. If that works well with few side effects, you might stick with it. If you need more power or experience mild side effects, your doctor may adjust it to 50 mg or 200 mg. The 200 mg dose isn’t for everyone—it’s usually reserved for those who didn’t respond to lower amounts and have no heart or liver issues. Never take more than one dose in 24 hours. Avanafil works best on an empty stomach. Eating a heavy, high-fat meal can delay how fast it kicks in, sometimes pushing the onset past an hour.

Avanafil isn’t for everyone. If you take nitrates for chest pain, you can’t use it—this combo can drop your blood pressure to dangerous levels. It also interacts with some antifungals, antibiotics, and HIV meds. People with liver disease, low blood pressure, or a history of stroke or heart attack should talk to their doctor first. And if you’ve ever had vision loss from ED meds like sildenafil, avoid Avanafil entirely.

Many people compare Avanafil to sildenafil (Viagra) or tadalafil (Cialis). Avanafil acts faster than Viagra and doesn’t last as long as Cialis, which can be a pro or con depending on your lifestyle. It’s also less likely to cause muscle aches or back pain than Cialis. But it’s pricier than generics. If you’ve tried other ED pills without success, Avanafil might be the missing piece.

Below, you’ll find real comparisons between Avanafil and other treatments—including combo pills like Super Avana that pair it with dapoxetine for both ED and premature ejaculation. You’ll also see how dosage changes for older adults, what to do if you miss a dose, and how alcohol or grapefruit juice can interfere. No fluff. Just what works, what doesn’t, and what your doctor won’t always tell you.